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目的：探讨短时受精联合早期补救ICSI（R-ICSI）的临床应用价值。方法回顾性分析行R-ICSI 31周期（Ⅰ组）与同期行ICSI 269周期（Ⅱ组），及移植补救ICSI解冻胚胎35周期（Ⅲ组）与同期移植非补救ICSI解冻胚胎1186周期（Ⅳ组）；比较Ⅰ组与Ⅱ组正常受精率、多精受精率、卵裂率、可移植胚胎率、优胚率及妊娠率；比较Ⅲ组与Ⅳ组妊娠率、流产率、活产率。结果Ⅰ组与Ⅱ组正常受精率、多精受精率、卵裂率、可移植胚胎率、优胚率及妊娠率均无显著性差异（P＞0.05）。Ⅲ组与Ⅳ组妊娠率、流产率及活产率均无显著性差异（P＞0.05）。结论短时受精联合R-ICSI可避免完全不受精的发生，是可行的。“,”Objective To evaluate the clinical value of rescue ICSI of unfertilized oocytes after short time insemination. Methods Retrospective study was performedin groupⅠ(included 31 cycles received early rescue ICSI), group Ⅱ (included 269 cycles of roution ICSI), groupⅢ (included 35 frozen-thawed cycles with transfer of embryos produced by rescue ICSI) and groupⅣ(included 1186 frozen-thawed cycles with transfer of embryos produced by ICSI). Rates of normal fertilization, polyspermy, cleavage, utilized embryo, good quality embryo, and pregnancy were comparatively analyzed between in groupI and in groupⅡ; rates of pregnancy, implantion, abortion and live birth were comparatively analyzed between in groupⅢand in groupⅣ. Results There were no significant differences in rates of normal fertilization, poly spermy, cleavage, utilized embryo, good quality embryo, and pregnancy between in groupⅠand in groupⅡ;there were no significant differences in rates of pregnancy, implantion, abortion and live birth between in groupⅢand in groupIV (P>0.05). Conclusion Early rescue ICSI 6h after short time insemination is an effective method to avoid fertilization failure.