许多研究已经证明扩血管药物对慢性难治性心力衰竭有一定疗效。有些药物已应用于临床,但均有其缺点。长效硝酸盐可降低左室充盈压,而且使用安全,但对心输出量的作用小。哌唑嗪(Prazosin)为强烈的小动脉扩张剂,但可产生耐药性。长厌定(Minoxidil)可引起多毛症及钠潴留。肼苯哒嗪(Hydralazine)长期使用可产生耐药性。因此必须继续寻找无严重副作用的扩血管药物。 Many studies have shown that vasodilator drugs have some effect on chronic refractory heart failure. Some drugs have been used clinically, but both have their drawbacks. Long-acting nitrates reduce left ventricular filling pressure and are safe to use, but have a small effect on cardiac output. Prazosin is a potent arteriolar dilator but produces resistance. Minoxidil can cause hirsutism and sodium retention. Hydralazine Long-term use can produce resistance. Therefore, we must continue to look for vasodilators without serious side effects.