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本文报告17例晚期血吸虫病患者用吡喹酮(60mg/kg,2天疗法)治疗前后的肌电图检查结果和吡喹酮对大鼠骨骼肌作用的实验观察结果。 动物实验显示吡喹酮能抑制电刺激对大鼠膈肌所致的收缩反应。在低浓度(0.1mM)时,使间接刺激的收缩幅度减小,对直接刺激则无影响。在高浓度(0.45mM)时,不仅使间接刺激的收缩幅度减小,且可使直
This article reports 17 patients with advanced schistosomiasis patients treated with praziquantel (60mg / kg, 2 days therapy) before and after treatment of electromyography and praziquantel experimental observation results of rat skeletal muscle. Animal experiments show that praziquantel can inhibit the contractile response of rat diaphragm caused by electrical stimulation. At low concentrations (0.1 mM), the indirect stimulation of the contraction rate decreases, the direct stimulation has no effect. At high concentrations (0.45 mM), not only did the magnitude of the indirect stimulus decrease, but the straight