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抗菌药物的体外杀菌活性和实际治疗效果并不总是一致,细菌的生长速率是影响因素之一.感染灶处的营养供应和温度变化不适于细菌的快速生长,因此细菌比体外常规条件下生长缓慢,倍增时间延长.已知β-内酰胺类抗生素杀菌活性与病原菌的倍增时间成正比,据报道喹诺酮类药物的活性与细菌的生长状况不相关.作者对环丙沙星、氧氟沙星、氟罗沙星、诺氟沙星对细菌不同状态的作用进行了研究.
The in vitro bactericidal activity of antibacterials is not always consistent with the actual therapeutic effect, and the growth rate of bacteria is one of the influencing factors.Nutritional supply and temperature change at the foci are not suitable for the rapid growth of bacteria, so the bacteria grew faster than the conventional in vitro conditions Slow, doubling the time extension.It is known β-lactam antibiotic bactericidal activity and pathogen doubling time is proportional to the reported activity of quinolones and bacterial growth status is not related to the author of ciprofloxacin, ofloxacin , Fleroxacin, norfloxacin on the role of different states of bacteria were studied.