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目的研讨罗红霉素、阿奇霉素在应用过程中引发不良反应(ADR)的情况。方法从我院2014年1月-2016年8月选取10例接受罗红霉素与阿奇霉素治疗后出现ADR的病例参与研究试验,对患者的临床资料、ADR类型等进行搜集、统计与回顾性分析。结果 10例患者中,罗红霉素所致ADR者4例,占40.0%,其中3例为胃肠系统反应,1例为中枢神经系统反应;阿奇霉素所致ADR有6例,占60.0%,包括皮肤反应、胃肠系统反应与中枢神经系统反应各有3例、2例和1例。结论临床在使用罗红霉素及阿奇霉素期间,需加强相关监测,特别是使用B型药物时,更不可忽视ADR的存在,以做到安全用药,高效治疗。
Objective To study the situation of roxithromycin and azithromycin inducing adverse reactions (ADR) in the course of application. Methods From January 2014 to August 2016 in our hospital, 10 cases of ADR patients who received roxithromycin and azithromycin were enrolled in the study. The clinical data, ADR types, etc. were collected, analyzed and retrospectively analyzed . Results Among 10 patients, there were 4 cases of ADR caused by roxithromycin (40.0%), 3 cases were gastrointestinal reaction and 1 case was central nervous system reaction. ADR caused by azithromycin was found in 6 cases (60.0%), Including skin reactions, gastrointestinal reactions and central nervous system reactions in 3 cases, 2 cases and 1 case. Conclusion Clinical use of roxithromycin and azithromycin during the need to strengthen the relevant monitoring, especially the use of type B drugs, but also can not ignore the presence of ADR in order to achieve safe medication and efficient treatment.