随着患者生存时间的延长,透析相关的长期并发症,如β_2-微球蛋白(β_2-microglobulin,简称β_2-MG,是由淋巴细胞、血小板、多形核白细胞产生的一种球蛋白,分子质量为11 800 u)沉积引起的淀粉样病变、皮肤瘙痒、顽固性高血压以及心血管合并症的发生逐渐增加,成为影响血液透析患者预后和生活质量的主要问题~([1])。如何清除中大分子是肾脏医学界的重要思考方向。目前认为,高通量血液透 With the prolongation of survival time of patients, the long-term complications associated with dialysis, such as β_2-microglobulin (β_2-MG), is a globulin, molecule produced by lymphocytes, platelets and polymorphonuclear leukocytes 11 800 u) The incidence of amyloid lesions, pruritus, intractable hypertension and cardiovascular comorbidity caused by deposition gradually increases and becomes a major problem affecting the prognosis and quality of life of hemodialysis patients. How to remove middle-big molecule is an important thinking direction of the kidney medical profession. Currently, high-flux hemodialysis