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目的:探讨月经正常的不同年龄段育龄女性血清硫酸脱氢表雄酮(DHEA-S)水平变化及其临床应用意义。方法:1 156名月经正常且年龄在21~45周岁的育龄女性为研究对象,按年龄分成5组,检测血清DHEA-S、bFSH、bLH及窦卵泡计数(AFC)水平。结果:年龄段在21~25岁、26~30岁、31~35岁、36~40岁、41~45岁妇女的血清DHEA-S 90%正常参考值范围分别为3.42~10.42μmol/ml、3.27~10.20μmol/ml、2.59~10.14μmol/ml、2.26~8.08μmol/ml、2.14~7.50μmol/ml。不同年龄组间血清DHEA-S水平比较差异有统计学意义(P<0.01),血清DHEA-S与年龄呈负相关,差异有统计学意义(r=-0.28,95%CI=5.78~6.03,P<0.01);血清DHEA-S与bFSH和bFSH/LH均呈负相关,DHEA-S与AFC呈正相关,差异均有统计学意义,r分别为-0.13、-0.08、0.592,95%CI分别为7.53~7.89、1.67~1.82、13.90~14.93,P<0.01。结论:随年龄增大,血清DHEA-S水平下降,可作为评估卵巢储备功能的一项参考指标,为临床诊治提供参考。
Objective: To investigate the change of serum level of DHEA-S in women of childbearing age with normal menstruation and its clinical significance. Methods: A total of 1 156 women of childbearing age with normal menstruation and 21 to 45 years of age were divided into five groups according to age. Serum DHEA-S, bFSH, bLH and AFC were measured. Results: The 90% normal reference values of DHEA-S in serum of 21-25 years old, 26-30 years old, 31-35 years old, 36-40 years old and 41-45 years old women were 3.42-10.42μmol / ml, 3.27 to 10.20 μmol / ml, 2.59 to 10.14 μmol / ml, 2.26 to 8.08 μmol / ml, 2.14 to 7.50 μmol / ml. There were significant differences in serum DHEA-S levels between different age groups (P <0.01), and serum DHEA-S was negatively correlated with age (r = -0.28, 95% CI = 5.78-6.03, P <0.01). Serum DHEA-S was negatively correlated with bFSH and bFSH / LH, while DHEA-S was positively correlated with AFC (r = -0.13, -0.08, 0.592 and 95% CI, respectively 7.53 ~ 7.89, 1.67 ~ 1.82, 13.90 ~ 14.93, P <0.01. CONCLUSIONS: With the increase of age, serum DHEA-S level declines, which can be used as a reference index to evaluate ovarian reserve function and provide reference for clinical diagnosis and treatment.