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目的:探讨肺炎支原体肺炎(MPP)患儿并发心血管系统损害的危险因素。方法:选取我院收治的241例MPP患儿为研究对象,收集患儿入院时的一般临床资料及实验室检查指标,按照是否并发心血管系统损害将患儿分为两组:心血管损害组和非心血管损害组,比较两组相关指标的差异,并对相关危险因素进行Logistic回归分析。结果:241例MPP患儿中有51例发生心血管系统损害(发生率21.2%);单因素分析提示:两组在年龄、急性期MP-Ab、胸腔积液、热程、血沉(ESR)、血清C反应蛋白(CRP)、白细胞计数(WBC)、血清CD4+/CD8+比值、发病7 d内应用大环内酯类药物、发病10 d内用药糖皮质激素存在统计学差异(P<0.05);二分类非条件Logistic回归分析提示:年龄、热程、胸腔积液、CRP是MPP患儿发生心血管系统损害的独立危险因素(P<0.05);血清CD4+/CD8+比值、发病7 d内应用大环内酯类药物则为保护性因素。结论:年龄、热程、胸腔积液、CRP是MPP患儿发生心血管系统损害的独立危险因素,而早期应用大环内酯类药物、及高CD4+/CD8+比值则为保护性因素,应当引起临床注意。
Objective: To explore the risk factors of cardiovascular system damage in children with Mycoplasma pneumoniae (MPP). Methods: A total of 241 children with MPP admitted to our hospital were enrolled in this study. The clinical data and laboratory indexes of children admitted to hospital were collected. The children were divided into two groups according to whether they had cardiovascular system impairment: cardiovascular injury group And non-cardiovascular damage group, comparing the difference between the two groups of related indicators, and related risk factors Logistic regression analysis. Results: Among the 241 children with MPP, 51 cases had cardiovascular system damage (the incidence rate was 21.2%). The univariate analysis showed that MP-Ab, pleural effusion, heat stroke, ESR, CRP, WBC, and serum CD4 + / CD8 + ratio within 7 days of onset of symptoms. Macrolides were used within 7 days after onset of symptoms, and there was a significant difference (P <0.05) Logistic regression analysis showed that age, thermal history, pleural effusion and CRP were independent risk factors of cardiovascular system damage in children with MPP (P <0.05). Serum CD4 + / CD8 + ratio within 7 days of onset Macrolides are protective factors. CONCLUSION: Age, heat stroke, pleural effusion and CRP are independent risk factors of cardiovascular system damage in MPP patients. However, early application of macrolides and high CD4 + / CD8 + ratio are protective factors and should cause Clinical attention.