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将小鼠分为“足三里”、静脉和皮下注射3组,每组分别于上午9时与下午9时注射速尿,作自身时辰对比。为待前一次药效充分消除,两次实验相间72小时,比较不同途径在上下午给药后尿量和尿钠含量。结果:三种给药途径组的尿量和尿钠含量上午均显著高于下午;上午给药后1小时的尿量,静脉组与“足三里”组几乎相等,两组均高于皮下组。本文表明,“足三里”、静脉、皮下3种给药途径注射速尿在利尿、利钠作用上均呈现同样的生物时辰节律。提示“足三里”组给药后1小时内的利尿效应和2小时内的利钠效应都与静脉组相当。
The mice were divided into three groups: “Zusanli”, intravenous and subcutaneous injections, and each group was injected with furosemide at 9:00 am and 9:00 pm respectively for comparison of their own time. In order to fully eliminate the previous efficacy, the two experiments were interphased for 72 hours, and the urine volume and urinary sodium content after administration in the previous and afternoon were compared between different routes. Results: The urine volume and urine sodium content in the three administration groups were significantly higher in the morning than in the afternoon; the urine volume, vein group, and the “Zusanli” group were almost equal in the morning one hour after administration, and both groups were higher than those in the morning. Subcutaneous group. This article shows that the injection of furosemide on the three routes of administration of “Zusanli”, intravenous, and subcutaneous all exhibit the same biological rhythm of diuresis and natriuresis. The diuretic effect within 1 hour after administration and the natriuretic effect within 2 hours were similar to that of the intravenous group in the prompt “Zusanli” group.