“高龄初产妇”的概念来源于1958年国际妇产科联合协会〔1〕,年龄≥35岁的初产妇称为高龄初产妇,其孕期并发症和胎儿染色体疾病的发生率明显高于非高龄产妇〔2〕。随着年龄的增长,妇女从青年进入中年时期,全身各个器官从功能旺盛阶段向衰退逐步过渡,其中以神经内分泌、生殖器官 The concept of “advanced primipara” originates from the International Union of Gynecology and Obstetrics, 1958 [1]. A primipara of ≥ 35 years old is called as an early primipara and has a significantly higher incidence of complications during pregnancy and fetal chromosomal diseases than non-advanced Maternal 〔2〕. With the growth of the age, women enter the middle age from the youth, and the organs of the whole body gradually transition from the functional stage to the recession. Among them, neuroendocrine, genital