目的：提高对新生儿表皮葡萄球菌（ｓｔａｐｈｙｌｏｃｏｃｃｕｓｅｐｉｄｅｒｍｉｄｉｓ，ＳＥ）败血症的认识及合理选用抗生素。方法：回顾性分析４１例血培养阳性的确诊新生儿表皮葡萄球菌（ＳＥ）败血症及体外药敏试验。结果：新生儿ＳＥ败血症缺乏特征性症状和体征。６５．８％患儿有气管插管、吸痰、机械通气治疗经历，６８．３％于生后一周内起病。药敏试验显示：耐５种及５种以上抗生素（多重耐药性）占７９．２％，其中对青霉素Ｇ耐药率最高（９０．２％），而对先锋霉素Ｖ和丁胺卡那霉素耐药率较低。结论：本症发生于有原发病的新生儿，治疗选用先锋霉素Ｖ和丁胺卡那霉素８９．７％有效 Objective: To improve the understanding of neonatal staphylococcusepidermidis (SE) sepsis and rational use of antibiotics. Methods: A retrospective analysis of 41 blood culture positive diagnosed neonatal Staphylococcus epidermidis (SE) sepsis and in vitro susceptibility testing. Results: Neonatal sepsis lacks characteristic signs and symptoms. 65.8% of children had endotracheal intubation, suctioning, mechanical ventilation experience, 68.3% onset within one week after birth. Susceptibility tests showed that the resistance to five and more than five antibiotics (multi-drug resistance) accounted for 79.2%, of which the highest rate of resistance to penicillin G (90.2%), and the Vanguard ADM and amikacin The resistance rate of namycin is low. Conclusion: The disease occurred in the primary disease of newborns, the choice of Pioneermycin V and amikacin 89.7% effective