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目的验证血片方法与血清方法应用于孕中期Down′s综合征产前筛查的一致性。方法同时对1096例孕15-20孕周孕中期孕妇血清以及滤纸干血片中的AFP及β-hCG含量进行了检测,对血清以及滤纸干血片中两分析物的浓度、中倍数进行了相关性分析,比较了两种方法的筛查结果。结果血清与血片中AFP及β-hCG含量呈高度相关,相关系数分别为0.979、0.982。血清与血片中AFP及β-hCGMoM呈高度相关,相关系数为0.968、0.975。当筛查切值为1/270时,血片法和血清法筛查假阳性率分别为6.4%和5.6%。结论血片与血清中AFP及β-hCG含量呈高度相关,血片方法和血清方法应用于孕中期Down′s综合征产前筛查一致性好,血片法可以代替血清法应用于孕中期Down′s综合征产前筛查。
Objective To verify the consistency of blood and serum methods in prenatal screening of Down’s syndrome during the second trimester of pregnancy. Methods The levels of AFP and β-hCG in 1096 pregnant women during the first trimester of pregnancy and the second and third trimester of pregnant women were measured. The concentration and middle multiple of two analytes Correlation analysis, comparing the screening results of the two methods. Results Serum and blood film AFP and β-hCG content was highly correlated, the correlation coefficients were 0.979,0.982. Serum and blood film AFP and β-hCGMoM were highly correlated, the correlation coefficient of 0.968,0.975. When the screening cut-off value was 1/270, the false-positive rates of blood film and serum screening were 6.4% and 5.6% respectively. Conclusions Blood film and serum AFP and β-hCG levels are highly correlated, blood film method and serum method used in the second trimester Down’s syndrome prenatal screening consistency, blood film method can be used instead of serum method in the second trimester Down’s syndrome prenatal screening.