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采用热等压技术将Tc4、HA、BGC以30∶35∶35比例混合烧结成生物活性微孔钛种植体。孔内复合bBMP移植成年狗颌骨与股骨中,经LM、SEM、FM、EDXA等检测.BMP组1周界面出现大量松骨细胞及骨基质沉积,成骨细胞活跃。生物力学测试:2周2.362MPa,对照组4周才达2.214MPa。种植体综合3种材料的优点,克服各自不足,不但可进行切削性加工,制成形态各异植入体。而且还可行颌骨缺损修复。与骨组织通过3相(Tio、HA、BGC)形成化学结合及物理、机械嵌合。BMP的加入使界面成骨活动提前启动和加强,但BMP并未改变种植体内在成分和骨性融合机制。
Tc4, HA and BGC were mixed and sintered in the ratio of 30:35:35 into biologically active microporous titanium implants by hot isobaric technology. Bone marrow complex bBMP transplantation of adult dog jaw and femur, by LM, SEM, FM, EDXA and other tests. A large number of osteoporosis and bone matrix deposition occurred on the interface of BMP group at 1 week, and osteoblasts were active. Biomechanical test: 2 weeks 2.362MPa, control group only reached 2.214MPa 4 weeks. Implant synthesis of the advantages of three kinds of materials to overcome their respective deficiencies, not only for machinability, made of various morphological implants. But also feasible jaw defect repair. And bone tissue through the 3 phase (Tio, HA, BGC) to form a chemical binding and physical, mechanical chimerism. The addition of BMP promoted the early activation of interface osteosynthesis, but BMP did not change the internal composition and osseous fusion mechanism.