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目的研究2型糖尿病(T2DM)合并冠心病患者脂质及载脂蛋白A1/载脂蛋白B(ApoA1/ApoB)变化的临床意义。方法收集本院收治的住院病人155例,按是否有冠心病分成两组,即A、B两组,A组为合并冠心病组,共60人;B组为不合并冠心病组,共95人。另外收集门诊健康体检病人作为对照组,即C组,共70人。比较三组间总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、ApoA1、ApoB及ApoA1/ApoB值。结果 A、B两组相比,A组TC、TG、LDL-C、ApoB较B组明显升高(P<0.05),HDL-C和ApoA1/B比值较B组明显下降,差异有统计学意义(P<0.05);与C组相比,A、B两组中HDL-C及ApoA1下降(P<0.05),TC、TG、LDL-C、ApoB水平升高,差异有统计学意义(P<0.05)。结论 2型糖尿病合并冠心病存在多种脂质代谢紊乱。血清HDL-C、ApoA1水平和ApoA1/ApoB值与2型糖尿病合并冠心病病变严重程度呈负相关。
Objective To study the clinical significance of the changes of lipid and apolipoprotein A1 / apolipoprotein B (ApoA1 / ApoB) in patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease. Methods A total of 155 inpatients admitted to our hospital were divided into two groups according to whether they had coronary heart disease or not, that is, group A and group B. Group A was coronary heart disease with 60 patients. Group B was coronary artery disease without coronary heart disease people. Another collection of out-patient health examination patients as a control group, that C group, a total of 70 people. The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), ApoA1, ApoB and ApoA1 / ApoB were compared between the three groups. Results The levels of TC, TG, LDL-C and ApoB in group A were significantly higher than those in group B (P <0.05), while the ratios of HDL-C and ApoA1 / B in group A and B were significantly lower than those in group B (P <0.05). Compared with group C, the levels of HDL-C and ApoA1 decreased (P <0.05) and the levels of TC, TG, LDL-C and ApoB increased in group A and group B P <0.05). Conclusion There are many lipid metabolism disorders in type 2 diabetic patients with coronary heart disease. The serum levels of HDL-C, ApoA1 and ApoA1 / ApoB were negatively correlated with the severity of coronary heart disease in type 2 diabetic patients.