由于大量化合物需要进行致畸性的研究,除了传统的哺乳动物致畸试验外,目前正积极发展各种体外的测试系统,包括除整体妊娠哺乳类动物外的其他生物测试系统。这些系统长期来用于生育异常的研究,最近才考虑其作为致畸化合物筛选方法的可能性,但一直没有找到一种体外试验可以理想地取代传统的致畸试验。 Due to the large number of compounds required for teratogenicity studies, in addition to traditional mammalian teratogenicity tests, a variety of in vitro test systems are being actively developed, including other biological testing systems in addition to whole-gravid mammals. These systems have long been used to study fertility abnormalities and have only recently been considered as possible screening methods for teratogenic compounds. However, no in vitro test has been found to be a perfect replacement for conventional teratogenicity tests.