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结晶型睾丸素:γ-环糊精(γ-CD)固体复合物的制备将1g睾丸素和57gγ-CD于500 ml水中,在25℃下搅拌7天,复合物沉淀析出微晶粉末,过滤后,室温干燥24h,用UV法分析粉末中睾丸素的含量,测得复合物的含量为10%,睾丸素:γ-CD复合物为1:2,分子量2882.溶解度试验是将片剂于一不锈钢筛网的吊篮中,吊篮放到搅拌的水浴中,然后进行测定.人血清中睾丸素的含量用放射免疫法测定.实验结果表明睾丸素和γ-CD在水中的相溶解度图是B_8型.当γ-CD浓度达到13mmol/L时,含两种成分的复合物从溶液中析
Preparation of Crystalline Testosterone: γ-Cyclodextrin (γ-CD) Solid Complex 1 g of testosterone and 57 g of γ-CD were dissolved in 500 ml of water and stirred at 25 ° C for 7 days. The complex precipitated into fine crystallized powder and was filtered After drying at room temperature for 24 h, the content of testosterone in the powder was analyzed by UV method, and the content of the compound was 10%. The testosterone: γ-CD complex was 1: 2 and the molecular weight was 2882. The solubility test A stainless steel mesh basket, the basket into a stirred water bath, and then measured in human serum testosterone content by radioimmunoassay.Experimental results show that the testis and γ-CD in water phase solubility diagram Is type B. When the concentration of γ-CD reaches 13 mmol / L, the complex containing two components is resolved from the solution