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目的 探讨人细小病毒B19(以下称B19)感染与特发性血小板减少性紫癜 (ITP)发病的关系。方法 对 5 2例ITP患儿及 32例健康儿童进行近期B19感染的检查 ,包括B19 DNA检查、间接免疫荧光法检测B19表面蛋白抗原 ;并比较ITP患儿中B19检测阴性及阳性患儿有关ITP的临床资料、实验室特征及预后。结果 5 2例ITP中B19 DNA阳性 12例 (2 3 1% ) ,健康儿童B19 DNA均为阴性 ,两组间差异有显著意义 (P <0 0 5 )。5 2例ITP患儿仅有 2例检测到B19抗原阳性 ,健康儿童所有标本均为阴性 ,两组间差别无显著意义 (P >0 0 5 )。5 2例ITP患儿B19检测阳性和阴性者中分别有 83 8% (10 /12 )和 5 0 % (2 0 /4 0 )的患儿初诊时病程 <2周 ;75 %(9/12 )和 4 0 % (16 /4 0 )入院时血小板计数呈重度低下 (<2 5 0× 10 9/L)。差别均有显著意义 (P <0 0 5 )。结论 B19感染可能为儿童ITP的重要病毒病原 ;B19感染者ITP起病似乎更急 ,血小板减低更明显。
Objective To investigate the relationship between infection of human parvovirus B19 (hereinafter referred to as B19) and idiopathic thrombocytopenic purpura (ITP). Methods A total of 52 children with ITP and 32 healthy children were examined for B19 infection in recent years, including B19 DNA test and indirect immunofluorescence test for B19 surface antigen. The levels of ITP in B19 negative and positive children with ITP The clinical data, laboratory characteristics and prognosis. Results 12 cases (21.3%) were positive for B19 DNA in 52 cases of ITP, and negative for B19 DNA in healthy children. There was significant difference between the two groups (P <0.05). Only 2 of 52 children with ITP had positive B19 antigen, and all healthy children were negative. There was no significant difference between the two groups (P> 0.05). Among the 52 children with ITP, 83.8% (10/12) and 50% (20/40) of the B19 positive and negative children respectively had a first course of disease less than 2 weeks and 75% (9/12 ) And 40% (16/40) had low (<250 × 10 9 / L) platelet counts on admission. The difference was significant (P <0 05). Conclusion B19 infection may be an important viral pathogen of childhood ITP. The onset of ITP in B19 infection appears to be more urgent and the thrombocytopenia is more obvious.