质子泵抑制剂（PPT）能够对胃壁细胞H+-K+-ATP酶加以抑制，让胃壁细胞内的H+无法进入胃腔，使胃酸分泌得到抑制。与H2受体阻滞剂相比较，PPI能够产生更强的抑酸程度，可以使胃内PH值得到有效提升，通过对比新老PPI抑制胃内PH值继而影响近端小肠内依赖PH值激活的消化酶，从而对胃肠道消化效率产生影响。本文主要对不同质子泵抑制剂对改善胃肠道症状和消化效率的影响进行探讨，以期能为临床实践提供参考。“,”Proton pump inhibitors(PPT)can of gastric parietal cels of H + - K + - ATP enzyme inhibited, let the parietal cels in the H + can not enter the stomach cavity, the secretion of gastric acid inhibition was obtained. Compared with H2 receptor blockers, the PPI can produce a stronger inhibition of acid degree, the pH in the stomach is to improve, through comparing the old and the new PPI inhibits gastric pH for then the impact of the proximal smal intestine dependent pH activation of digestive enzyme, thus on the gastrointestinal tract of the digestive efficiency. In this paper, the effects of different proton pump inhibitors on improving gastrointestinal symptoms and digestion efficiency were discussed, in order to provide reference for clinical practice.