众多研究表明 ,肝细胞线粒体的损伤在重症感染合并多器官功能障碍综合征 (ＭＯＤＳ)的发病中出现最早 ,程度最显著 ,并且影响着机体器官之间能量及代谢底物的交换平衡〔1〕。线粒体是典型的双膜细胞器 ,具有外膜、内膜、膜间间隙和基质。线粒体内膜是氧化磷酸化的重要场所 ,全 Numerous studies have shown that mitochondrial damage in hepatocytes occurs most prominently in the onset of severe infection combined with multiple organ dysfunction syndrome (MODS), and affects the exchange balance of energy and metabolic substrates between organs (1) . Mitochondria are typical bilayer organelles with outer membrane, inner membrane, intermembrane space and matrix. Mitochondrial inner membrane is an important place for oxidative phosphorylation, all