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目的：探讨肥胖对非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者左心室功能的影响。方法：采用超声心动图检测１８３例非胰岛素依赖型糖尿病患者左心室功能及结构参数。结果：不论血压正常或是合并高血压的非胰岛素依赖型糖尿病患者，随体重指数增大舒张期二尖瓣口血流频谱Ａ峰与Ｅ峰峰值流速比值（ＰＶＡ／ＰＶＥ）、每搏输出量、左心室重量指数均增加，二尖瓣前叶斜率、射血分数、短轴缩短率均降低，以血压正常者变化为著；舒张末期心室间隔厚度与左心室后壁厚度比值（ＩＶＳＴｄ／ＬＶＰＷＴｄ）则无变化。合并高血压的非胰岛素依赖型糖尿病患者较血压正常者有较高的ＰＶＡ／ＰＶＥ、ＩＶＳＴｄ／ＬＶＰＷＴｄ和左心室重量指数，而二尖瓣前叶斜率较低。结论：肥胖可诱发非胰岛素依赖型糖尿病患者左心室收缩功能异常并加重舒张功能损害。
Objective: To investigate the effect of obesity on left ventricular function in patients with non-insulin dependent diabetes mellitus (NIDDM). Methods: Echocardiography was used to detect left ventricular function and structural parameters in 183 patients with non-insulin dependent diabetes mellitus. Results: In patients with non-insulin-dependent diabetes mellitus (normotensive or with hypertension), the body mass index increased the ratio of peak A to peak E / A peak velocity (Vp / PVE), stroke volume , Left ventricular mass index increased, mitral valve anterior slope, ejection fraction, short axis shortening rate were reduced to normotensive persons as a; end-diastolic ventricular septal thickness and left ventricular posterior wall thickness ratio (IVSTd / LVPWTd ) No change. Patients with non-insulin-dependent diabetes mellitus with hypertension had higher rates of PVA / PVE, IVSTd / LVPWTd and left ventricular mass index than those with normotension, whereas mitral valve slope was lower. Conclusion: Obesity can induce left ventricular systolic dysfunction and increase diastolic dysfunction in non-insulin-dependent diabetic patients.