人们认为人实体瘤的发展是多步骤的,包括癌基因的激活和肿瘤抑制基因(TSGS)的失活。通过筛选杂和性丢失(LOH)可提示隐匿TSGS的基因组部位。对浸润性卵巢癌的研究已表明在多种染色体上有改变。在含有已知或被怀疑TSGS的多个位点上的LOH在一些肿瘤中与临床结果有关,并且有预后价值。 边缘上皮卵巢瘤以上皮细胞无破坏性基质浸润的扩增能力为特征。患有该肿瘤的病人临床预后和存活率都好于有破坏性基质浸润的病人。然而在良性和边缘卵巢瘤有发展成癌的潜在性这一问题上仍存在分岐。有人在侵入性瘤和边缘癌中发现了K-ras原癌基因的普通 It is thought that the development of human solid tumors is multi-step including activation of oncogenes and inactivation of tumor suppressor genes (TSGS). Screening for loss of heterozygosity (LOH) may prompt concealment of the genomic portion of TSGS. Studies on invasive ovarian cancer have shown to change on a variety of chromosomes. LOH at multiple sites containing known or suspected TSGS is associated with clinical outcome in some tumors and has prognostic value. Marginal epithelial ovarian tumors are characterized by the ability of epithelial cells to proliferate without destructive matrix infiltration. Patients with this tumor have a better clinical outcome and survival rate than patients with destructive matrix infiltration. However, there are still differences in the potential for benign and marginal ovarian tumors to develop into cancers. Someone has found the common K-ras protooncogene in invasive and borderline cancers