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目的 探讨抗精子抗体（ＡｓＡｂ）与抗子宫内膜抗体（ＥＭＡｂ）在不孕、流产中的作用及二者关系，进一步 揭示不孕、流产的病因。方法 采用酶联免疫吸附试验（ＥＬＩＳＡ）同时检测３４５例不孕、流产妇女血清中的ＡｓＡｂ与 ＥＭＡｂ，按ＡｓＡｂ检测结果分阳性组和阴性组，比较两组ＥＭＡｂ阳性率的差异。结果 原发不孕及自然流产妇女中， ＡｓＡｂ（－）组ＥＭＡｂ阳性率高达１６．６７％和１９．５１％，而ＡｓＡｂ（＋）组ＥＭＡｂ阳性率高达４３．６４％和４２．８６％，显著高于 ＡｓＡｂ（－）组（Ｐ＜０．０１，Ｐ＜０．０５）。继发不孕妇女中ＡｓＡｂ（－）组ＥＭＡｂ阳性率为１８．１８％，ＡｓＡｂ（＋）组ＥＭＡｂ阳性率 为３２．２％，二者无显著性差异（０．０１＞Ｐ＞０．０５）。结论原发不孕及自然流产妇女中因个体免疫反应差异使某些 人易对体内、外物质发生免疫反应而产生抗体，从而导致不孕或流产。
Objective To investigate the role of anti-sperm antibody (AsAb) and anti-endometrial antibody (EMAb) in infertility and miscarriage and their relationship to further reveal the causes of infertility and miscarriage. Methods Serum AsAb and EMAb in 345 cases of infertility and abortion women were detected by enzyme-linked immunosorbent assay (ELISA). The differences of positive rates of EMAb between the two groups were compared according to AsAb test results. Results In women with primary infertility and spontaneous abortion, the positive rates of EMAb in AsAb (-) group were as high as 16.67% and 19.51%, while those in AsAb (+) group were 43.64% and 42.86%, respectively. Was significantly higher than that of AsAb (-) group (P <0.01, P <0.05). The positive rate of EMAb in AsAb (-) group was 18.18% and the positive rate of EMAb in AsAb (+) group was 32.2% in secondary infertile women, with no significant difference (0.01> P> 0.05 ). Conclusion Some women are prone to produce antibodies due to the difference of individual immune response in some women with primary infertility and spontaneous abortion because of their immune response to both in vivo and exogenous substances, resulting in infertility or miscarriage.