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大肠癌是最常见恶性肿瘤之一。肿瘤多药耐药现象（ｍｕｌｔｉｄｒｕｇｒｅｓｉｓｔａｎｃｅ，ＭＤＲ）是近年来基础及临床肿瘤学科研究热点之一，ＭＤＲ是指肿瘤细胞对结构功能作用机制各不相同的多种抗肿瘤药物产生交叉耐药。现已证实人类肿瘤ＭＤＲ主要是由ｍｄｒ１基因编码?
Colorectal cancer is one of the most common malignant tumors. Multidrug resistance (MDR) is one of the research hotspots in basic and clinical oncology in recent years. MDR refers to the cross-resistance of tumor cells to a variety of antitumor drugs with different structural and functional mechanisms. Has it been confirmed that human tumor MDR is mainly encoded by mdr1 gene?