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目的：探讨ＥＰ、ＣＥ方案化疗失败肺癌病人的补救治疗。方法：本文采用由异环磷酰胺、顺铂、鬼臼已叉甙组成的ＶＩＰ方案治疗了３９例接受ＥＰ、ＣＥ方案化疗后无效或复发的小细胞肺癌患者，平均化疗３１周期。结果：完全缓解２例，部分缓解１８例，总有效率５１３％。进一步分析表明无效病例的有效率明显高于复发病例，而进展率则明显低于复发病例。主要不良反应为骨髓抑制和胃肠道反应，结论：ＶＩＰ方案具有较好的耐受性和安全性，在小细胞肺癌的补救治疗中具有一定的应用价值
Objective: To investigate the salvage treatment of patients with lung cancer who failed chemotherapy with EP and CE regimens. Methods: Thirty-nine patients with inoperable or relapsed small cell lung cancer treated with EP or CE regimens were treated with a VIP regimen consisting of ifosfamide, cisplatin, and podophyllotoxin, and the mean duration of chemotherapy was 3-1 cycles. Results: Complete remission in 2 cases, partial remission in 18 cases, total effective rate of 51. 3%. Further analysis showed that the effective rate of invalid cases was significantly higher than that of recurrent cases, and the rate of progress was significantly lower than that of recurrent cases. The main adverse reactions were myelosuppression and gastrointestinal reactions. Conclusion: The VIP regimen is well tolerated and safe. It has certain application value in the rescue treatment of small cell lung cancer.