桥脑中央髓鞘溶解是一种原因不明的桥脑基底部原发性脱髓鞘疾病,最初认为和酒精中毒有关,但许多病例并不涉及酒精中毒。同本病有关的其他因素包括中毒、营养不良及其他营养缺乏状态、慢性消耗、脑缺血、脑水肿、脂肪代谢障碍、感染、肝功能障碍、个体素质、脱水、渗透压波动,抗利尿激素分泌不当以及电介质异常。本文报告一例严重低血钠伴桥脑中央髓鞘溶解: Central pontine myelinolysis is an unexplained primary demyelinating disease at the base of the pons and was initially thought to be associated with alcoholism but many cases do not involve alcoholism. Other factors associated with this disease include poisoning, malnutrition and other nutritional deficiencies, chronic consumption, cerebral ischemia, cerebral edema, lipodystrophy, infection, liver dysfunction, individual diathesis, dehydration, osmotic pressure fluctuations, antidiuretic hormone Improper secretion and dielectric abnormalities. This article reports a case of severe hyponatremia with pontine myelinolysis: