论文部分内容阅读
DNA甲基化参与基因的表达调控。 DNA甲基化异常与肿瘤等疾病有关 ,抑癌基因启动子区的异常甲基化和癌基因的去甲基化均影响肿瘤发生发展过程。肿瘤细胞的总体甲基化水平比正常细胞低 ,但是伴有某些Cp G岛甲基化程度增高
DNA methylation participates in gene expression regulation. DNA methylation abnormalities and cancer and other diseases related to tumor suppressor gene promoter region of abnormal methylation and oncogenes demethylation both affect tumor development process. The overall methylation level of tumor cells is lower than that of normal cells, but with increased methylation of some CpG islands