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作者在1950～1980年间应用肌注链霉素治疗梅尼埃病20例,年龄由33～67岁,观察1～16年,13男,7女,14例双侧,6例单侧。链霉素用量由每12小时0.75～1.75克不等(每天1.5～3.5克),并由每日1克开始观察不平衡征象。通常头一周无反应,而后大多数病人共济失调加重,热反应逐渐降低,治疗持续到患耳对冰水试验无反应为止。共济失调可由强制行走锻炼恢复。其中19例阵发性眩晕完全消失。全部20例(40只耳)平均观察7.8年,30只耳听力无改变,6只耳听力提高,4只耳听力
In 1950-1980, 20 cases of Meniere’s disease were treated with streptomycin, ranging from 33 to 67 years old. The observation ranged from 1 to 16 years, 13 males and 7 females, 14 cases were bilateral and 6 cases were unilateral. The amount of streptomycin varied from 0.75 to 1.75 grams every 12 hours (1.5 to 3.5 grams per day), and imbalance signs were observed from 1 gram daily. Usually no response in the first week, and then most patients ataxia aggravate, gradually reduce the thermal response, the treatment continues until the ear does not respond to ice water test so far. Ataxia can be recovered by walking exercise. 19 cases of paroxysmal vertigo disappeared completely. All 20 cases (40 ears) observed an average of 7.8 years, 30 ears had no change in hearing, 6 ears improved hearing, 4 ears hearing