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二氯甲烷中,苯甲酸在三苯膦(1.5倍摩尔量)、I_2(1.5倍摩尔量)和Et_3N(3倍摩尔量)催化下,0~25℃与苯酚(1.1倍摩尔量)反应生成相应苯甲酸苯酯,27例收率67%~99%。苯甲酸pK_a值及其取代基位阻对反应无影响;苯酚邻位位阻较
In dichloromethane, benzoic acid reacts with phenol (1.1-fold molar amount) at 0-25 ° C under the catalysis of triphenylphosphine (1.5 times molar amount), I 2 (1.5 times molar amount) and Et 3 N (3 times molar amount) The corresponding phenyl benzoate, 27 cases of 67% to 99% yield. Benzoic acid pK_a value and the steric hindrance of the substituent had no effect on the reaction; phenol ortho steric resistance