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诺氟沙星为氟喹诺酮类衍生物,具有强大的抗菌活性,尤其对金黄色葡萄球菌及包括绿脓杆菌在内的革兰阴性细菌有很强作用。诺氟沙星现已由口服制剂发展为注射剂。诺氟沙星葡萄糖注射液(以下简称ING)已广泛应用于临床。临床上中常将ING与其它注射液配使用,但对其注射液中发生的物理,化学、微粒变化,目前尚未见报道。为探讨该药配伍应用的合理性,我们进行了几组实验研究。现报告如下。
Norfloxacin is a fluoroquinolone derivative with strong antibacterial activity, especially against Staphylococcus aureus and Gram-negative bacteria including Pseudomonas aeruginosa. Norfloxacin has evolved from an oral formulation to an injection. Norfloxacin glucose injection (hereinafter referred to as ING) has been widely used in clinical. ING and other injections are commonly used in clinical practice, but the physical, chemical and microparticle changes that occur in the injection have not been reported yet. To explore the compatibility of the compatibility of the drug, we conducted several experimental studies. The report is as follows.