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Our knowledge of the physiology of ion channels has increased tremendously during the past 20 years because of the advances of the single-channel recording and molecular cloning techniques. More than 50 different identified potassium channels have already been found.~(1,2) They are distributed ubiquitously in wide variety of cells including airway smooth muscle (ASM) cells and inflammatory cells in airway such as eosinophils, basophils, macrophages and so on.~3 Several types of K~+ channels have been identified in ASM cells, e.g., a large-conductance, voltgage-dependent Ca~(2+)-activated K~+ channel(BK_(Ca)), a voltage-dependent delayed-rectifier K~+ channel(Kv), and an ATP-sensitve K~+ channel(K_(ATP)).~1 In such excitable cells,
Our knowledge of the physiology of ion channels has increased tremendously during the past 20 years because of the advances of the single-channel recording and molecular cloning techniques. are distributed ubiquitously in a wide variety of cells including airway smooth muscle (ASM) cells and inflammatory cells in airways such as eosinophils, basophils, macrophages and so on. ~ 3 Several types of K ~ + channels have been identified in ASM cells, eg, a large-conductance, voltgage-dependent Ca ~ (2 +) - activated K ~ + channel (BK Ca), a voltage-dependent delayed-rectifier K ~ + channel channel (K_ (ATP)). ~ 1 In such excitable cells,