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一、利福平:利福平是一种对患者有良好耐受而很少引起严重毒性的药物,但它能引起肝炎,因此,这种药物给予慢性肝病患者,包括酒精中毒者,就必须测定肝功能。由于利福平能诱导肝微粒体酶,因而,可降低皮质类甾醇、地戈辛、香豆素、抗凝血剂、口服避孕药、口服降糖剂(磺酰脲类和双胍类)、麻醉和镇痛剂类(美散痛、吗啡、苯巴比妥)和氨苯砜等药物的血浆半衰期及临床效能。大剂量给予大鼠和小鼠尚有致畸作用,但对人体胎儿的危害却无令人信服的依据。必须告知病人,应用该药可使尿及其他分泌物显红色。
Rifampicin: Rifampicin is a drug that is well tolerated by patients and seldom causes serious toxicity, but it can cause hepatitis. Therefore, the drug must be given to patients with chronic liver disease, including those with alcoholism Determination of liver function. Since rifampin induces liver microsomal enzymes, corticosteroids, digoxigenin, coumarins, anticoagulants, oral contraceptives, oral antidiabetic agents (sulfonylureas and biguanides) can be reduced, Plasma half-lives and clinical efficacy of drugs such as narcotic and analgesic agents (bFGF, morphine, phenobarbital) and dapsone. Large doses of rats and mice are still teratogenic effects, but the harm to the human fetus there is no convincing basis. Must inform the patient, the application of the drug can make urine and other secretions red.