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目的 :观察人参皂苷Rg2 对失血性休克犬血流动力学的影响及抗氧化作用。方法 :复制杂种犬失血性休克失代偿期病理模型 ,动脉放血至平均动脉压 (MBP)在 5 .33kPa以下 ,然后给予Rg2 0 .5 ,1mg·kg-1,参麦(SM) 10 0mg·kg-1,iv。观察 6h。结果 :人参皂苷Rg2 能明显升高失血性休克失代偿期犬MBP、左室内压 (LVSP)和左室内压最大变化速率 (±dp/dt) ;增强血清超氧化物歧化酶 (SOD)的活性 ,降低血清丙二醛 (MDA)含量 ;提高休克犬的存活率。结论 :人参皂苷Rg2 能明显改善失血性休克犬血流动力学多项指标 ,激活机体抗氧化能力 ,作用强于SM。
Objective: To observe the effect of ginsenoside Rg2 on hemodynamics and antioxidation of hemorrhagic shock dogs. METHODS: The pathological model of decompensated hemorrhagic shock in canine dogs was reproduced. The arterial blood pressure was reduced to mean arterial pressure (MBP) below 5.33 kPa, and then Rg2 0.5, 1 mg kg-1, and SM 100 mg were given. ·kg-1,iv. Observe 6h. RESULTS: Ginsenoside Rg2 can significantly increase the maximum rate of change of MBP, left ventricular pressure (LVSP), and left ventricular pressure (±dp/dt) in dogs with decompensated hemorrhagic shock; enhanced serum superoxide dismutase (SOD) levels. Activity, reduce serum malondialdehyde (MDA) content; increase the survival rate of shock dogs. Conclusion : Ginsenoside Rg2 can significantly improve the hemodynamic parameters of hemorrhagic shock dogs and activate the body’s antioxidant capacity. The effect of ginsenoside Rg2 is stronger than that of SM.