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播散性球孢子菌病是一种全身性霉菌感染,多发生于防御机能损伤——细胞介导免疫缺陷的病人.而在肾移植病人中并发播散性球孢子菌病更是一种严重的疾病,其诊断后第一年的死亡率超过50%.本文报告1例肾移植病人应用免疫抑制药后并发播散性球孢子菌病,经常规治疗失败后试用撤除免疫抑制药治疗本病的结果.患者男,20岁.因发热、厌食、不适、体重减轻2月,咳嗽、头痛3周于1977年9月入院.患者在1973年行肾移植(其兄弟供体HLA与其不同),嗣后,一直应用免疫抑制药——隔日用强的松30mg和硫唑嘌呤50mg/天治疗.入院时胸透见有弥漫的结节性间质浸润;脑脊液显示白细胞增多、蛋白增加和糖
Disseminated coccidioidomycosis is a systemic fungal infection that occurs mostly in patients with impaired defense-cell-mediated immune deficiency, and is associated with disseminated coccidioidomycosis in renal transplant patients Of the disease, the first year after diagnosis of the mortality rate of more than 50% .This paper reports 1 case of renal transplant patients with immunosuppressive drugs and disseminated coccidioidomycosis, after conventional treatment failed to remove immunosuppressive drugs in the treatment of this disease Male, 20 years old due to fever, anorexia, malaise, weight loss February, cough, headache for 3 weeks were admitted to hospital in September 1977. The patient underwent kidney transplantation (his brother donated HLA was different from it) in 1973, Subsequently, immunosuppressive drugs have been used - every other day with prednisone 30mg and azathioprine 50mg / day treatment admitted to the thoracoscopic see diffuse nodular interstitial infiltration; CSF showed leukocytosis, increased protein and sugar