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辅助生殖技术(assisted reproductive technology,ART)已经成为治疗不孕症的有效方法。但近年来一些研究指出,ART可能增加基因印记紊乱的发病风险,而DNA甲基化修饰则是其重要机制。ART干预了基因印记发生的主要阶段,即配子发育和胚胎植入前阶段,可能造成11p15、15q11-13等区域相关基因DNA甲基化异常,导致一些相关疾病的的发病风险增高。但其相关性仍待进一步探索,而我们也需要不断改进操作技术来提高ART的遗传安全性。
Assisted reproductive technology (ART) has become an effective method of treating infertility. However, some studies in recent years pointed out that ART may increase the risk of gene imprinting disorder, and DNA methylation modification is its important mechanism. ART intervenes in the main stages of gene imprinting, that is, gametophyte development and preimplantation stage, which may lead to DNA methylation abnormalities in 11p15, 15q11-13 and other related regions, leading to an increased risk of some related diseases. However, its relevance remains to be further explored, and we also need to continually improve operational techniques to improve the genetic safety of ART.