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体外研究表明,雷尼酸锶能够增强成骨细胞的增殖,进而增加其成骨活性。同时,雷尼酸锶能剂量依赖性地降低破骨细胞的活性。体内研究显示,雷尼酸锶能降低骨再吸收,维持骨形成保持在一个较高水平,并且防止骨丢失,而且可将骨形成和骨再吸收有效地解偶联,使处于生长期动物的骨增长、骨几何学形状和微观结构得到改善。雷尼酸锶处理未经阉割的雌性大鼠2年后,发现椎骨和中段股骨的骨机械性能得到显著增强。所有骨强度的决定因素如骨量、尺寸、微观结构以及骨质明显受到影响。骨机械性能增加的特征是最大负荷的增加以及抗损伤能力的显著改善,本质是其塑性的增加,这与骨质自身修复过程是相一致的。实验结果表明,在雷尼酸锶处理下形成的新骨在骨折前能够承受更剧烈的变形应力。此外,雷尼酸锶的处理能够防止卵巢切除术对骨强度的有害影响。动物模型经过1年时间雷尼酸锶处理,能有效地阻止椎骨机械性能的改变,并部分保留骨小梁的微观结构:剂量依赖性影响骨体积/小梁体积的比率、小梁数目和厚度。
In vitro studies show that strontium ranelate can enhance the proliferation of osteoblasts, thereby increasing their osteogenic activity. Meanwhile, strontium ranelate dose-dependently reduced osteoclast activity. In vivo studies have shown that strontium ranelate reduces bone resorption, maintains bone formation at a high level, and prevents bone loss, but also uncouples bone formation and bone resorption effectively, allowing animals in growing stages Bone growth, bone geometry, and microstructure improved. Two years after treatment with strontium raneinate in non-castrated female rats, the mechanical properties of the vertebral and mid-femur bone were found to be significantly enhanced. All bone strength determinants such as bone mass, size, microstructure, and bone mass are clearly affected. The increase in mechanical properties of the bone is characterized by an increase in maximum load and a significant improvement in the resistance to injury, the nature of which is an increase in its plasticity that is consistent with the repair of the bone itself. The experimental results show that the new bone formed under the strontium ranelate treatment can withstand more severe deformation stress before fracture. In addition, the treatment of strontium ranelate can prevent the deleterious effects of ovariectomy on bone strength. The animal model treated with strontium ranelate for 1 year effectively prevented changes in vertebral mechanical properties and partially preserved the microstructure of trabecular bone: the dose-dependent ratio of volume of bone / trabecular volume, the number and thickness of trabeculae .