目的探讨糖尿病早期肾损伤尿微量白蛋白(UmAlb)值的变化。方法采用免疫比浊法测定尿中微量白蛋白(mAlb)含量。结果糖尿病患者24小时尿mAlb值较正常对照组增高(P<0.01),糖尿病患者中尿蛋白定性阴性的患者随机尿mAlb值也较正常对照组显著增高(P<0.01)。结论尿mAlb的检测是诊断糖尿病早期肾损伤敏感、准确的实验室指标之一。 Objective To investigate the changes of urinary microalbuminuria (UmAlb) in diabetic nephropathy. Methods Urinary microalbumin (mAlb) was determined by immunoturbidimetry. Results The diastolic blood mAb level in diabetics was significantly higher than that in the control group (P <0.01). The diastolic blood plasma mAlb was also significantly increased in diabetic patients with negative urine protein (P <0.01). Conclusion The detection of urinary mAlb is one of the sensitive and accurate laboratory indicators for the diagnosis of diabetic early renal injury.