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肝纤维化是肝硬化的病理基础,也是各种慢性肝病向肝硬化发展的必经阶段。早期诊断肝纤维化有利于临床早期抗纤维化治疗,以阻断或延缓肝硬化的形成。肝穿刺活检因其创伤性而限制了临床上的常规开展,因此寻找简便而有效的肝纤维化血清标志物成为近年来肝病研究的热点。据文献报道,血清中Ⅳ型胶原的浓度可以灵敏地反映肝纤维化的程度,并与肝内Ⅳ型胶原的浓度呈正相关。本文测定了111例各种肝病患者血清中Ⅳ型胶原的含量,并与正常人对照作了比较,结果报告如下。
Liver fibrosis is the pathological basis of cirrhosis, but also a necessary stage for the development of various chronic liver diseases to cirrhosis. Early diagnosis of liver fibrosis is conducive to clinical early anti-fibrosis treatment to block or delay the formation of cirrhosis. Liver biopsy has limited clinical routine due to its trauma. Therefore, finding a simple and effective serum marker of liver fibrosis has become a hot topic in liver disease research in recent years. According to the literature, the concentration of type Ⅳ collagen in serum can sensitively reflect the degree of liver fibrosis and is positively correlated with the concentration of type Ⅳ collagen in the liver. This article measured 111 cases of liver disease in patients with serum levels of type Ⅳ collagen and compared with the control of normal people, the results reported below.