外源性雌激素治疗已广泛应用于绝经后妇女。有人调查在某一大城市有半数以上的绝经后妇女使用雌激素至少在三个月以上(中数期10年)。这一问题本身已成为重要的公共卫生方针问题。若因此而伴有全国宫内膜癌发病数增加时就成为一个更为紧迫的问题。此外,外源性雌激素可能有减轻和延缓骨质疏松,防止髋骨、桡骨骨折和改善绝经期症状的作用。应该把这些收益和宫内膜癌、胆囊疾病的危险性加以权衡,且对两者的费用加以对照,费用不但包括直接的治疗费用和治疗副作用的费用,还包括宫内膜癌,胆囊切除和预防骨折的费用。本文采取前瞻性观察评价绝经后妇女对 Exogenous estrogen therapy has been widely used in postmenopausal women. It has been investigated that more than half of postmenopausal women in a large city use estrogen for at least three months (a median of 10 years). This issue has become an important issue of public health policy itself. If this is accompanied by an increase in the incidence of endometrial cancer in the country, it becomes a more pressing problem. In addition, exogenous estrogen may reduce and delay osteoporosis, prevent hip and tibia fractures, and improve menopausal symptoms. These benefits should be weighed against the risk of endometrial cancer and gallbladder disease, and the cost of the two should be weighed. The cost includes not only the direct treatment costs and the costs of treating side effects, but also endometrial cancer, cholecystectomy and The cost of preventing fractures. This article uses a prospective observation to evaluate postmenopausal women