论文部分内容阅读
1958～1988年30年间,中国医学科学院肿瘤医院共收治64例子宫肉瘤(36例子宫恶性苗勒氏混合瘤、18例子宫平滑肌肉瘤、10例子宫内膜间质异位症)。以核分裂像作为子宫平滑肌肉瘤及子宫内膜间质异位症的诊断标准,2年及5年生存率分别为53％及42％。子宫内膜间质异位症患者的5年生存率最高达100%,子宫平滑肌肉瘤为56％,而子宫恶性苗勒氏混合瘤最低,仅为18%。12例子宫恶性苗勒氏混合瘤既往有放射治疗史。临床分期及年龄是重要的预后因素。单纯手术治疗者及手术辅以化疗和/或放疗者的5年生存率分别为48%及43%(P>0.05),两组生存率比较无显著性差异。手术切除肿瘤是主要的治疗方式。多数学者提出应手术辅以化疗和/或放疗,但效果尚难肯定。该组27例复发病例中,局部复发占44%,远处转移占33%,其中80%的患者于首次治疗后2年内复发;82％的复发者于复发后2年内死亡。
In the 30 years from 1958 to 1988, 64 cases of uterine sarcoma (36 cases of mixed Müllerian mixed tumor, 18 cases of uterine leiomyosarcoma and 10 cases of endometrial stromal disease) were treated in Cancer Hospital of Chinese Academy of Medical Sciences. With mitotic figures as the diagnostic criteria for uterine leiomyosarcoma and endometrial stromal disease, the 2-year and 5-year survival rates were 53% and 42%, respectively. Endometrial stromal disease in patients with 5-year survival rate of up to 100%, 56% of uterine leiomyosarcoma, while the lowest Müllerian mixed tumor of the uterus, only 18%. Twelve patients with malignant Müllerian mixed tumor had a history of radiation therapy. Clinical stage and age are important prognostic factors. The 5-year survival rates of patients who underwent surgery alone and those who underwent chemotherapy and / or radiotherapy were 48% and 43%, respectively (P> 0.05). There was no significant difference in survival between the two groups. Surgical resection of the tumor is the main treatment. Most scholars suggest that surgery should be supplemented with chemotherapy and / or radiotherapy, but the effect is difficult to confirm. In the group of 27 cases of recurrence, the local recurrence accounted for 44%, distant metastasis accounted for 33%, of which 80% of the patients relapsed within 2 years after the first treatment; 82% of the recurrences died within 2 years after recurrence.