论文部分内容阅读
为了确定口服避孕药对血浆雄激素及其前体的影响,本文对89例使用含雌激素口服避孕药6个月以上的妇女及与其年龄相仿(18～35岁)月经规则的47名妇女对照,测定其血浆脱氢表雄酮(DHEA)及其硫酸脂(DHEAS)和雄烯二酮(A_2)以及其前体△~5-孕烯醇酮(△~5-P)和17α-羟孕烯醇酮(17α-△~5-p)的含量。采血时间为月经周期第15～20天的早晨7～8时。血浆DHEAS、DHEA和A_2测定结果表明三种含雌激素的口服避孕药(Ovral、Demnlen50、OrthoNovum 1/50)均可引起血浆雄激素含量下
In order to determine the effect of oral contraceptives on plasma androgens and their precursors, 89 women who used estrogen-containing oral contraceptives for more than 6 months and 47 women with similar menstruation (age 18-35) The plasma levels of DHEA and DHEAS and androstenedione (A 2) and their precursors △ 5 -pregnanone (△ 5-P) and 17α-hydroxy pregnane Enolate (17α-Δ ~ 5-p) content. Blood collection time for the first 15 to 20 days of the menstrual cycle in the morning 7 to 8:00. The results of plasma DHEAS, DHEA and A_2 showed that three estrogen-containing oral contraceptives (Ovral, Demnlen50, OrthoNovum 1/50) all induced plasma androgen levels