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对从未服过避孕药的正常妇女10名,晚期妊娠妇女12名和服避孕药妇女13名的外周血淋巴细胞染色单体交换频率进行了观察。 服药组用复方炔雌醚(炔雌醚3.3mg,氯地孕酮15mg),每月一片,平均9.04年(8～11年),继用减量复方炔雌醚(炔雌醚2mg,氯地孕酮6mg,18甲基炔诺酮6mg),平均1.04年1～1.5年)。 三组的平均姐妹染色单体交换频率分别为:5.45士1.10SD,7.15土1.22SD和5.98士1.13SD,此结果显示服药组与正常妇女组之间的姐妹染色单体交换频率无统计学差异,而妊娠组比服药组和正常妇女组的姐妹染色单体交换频率高。说明本研究中未见适当使用本避孕片增加姐妹染色单体交换频率。
The frequencies of chromatid exchange in peripheral blood lymphocytes from 10 normal women who had never taken contraceptives, 12 late pregnant women and 13 women who took birth control pills were observed. The medication group with compound ethynylestradiol (ethinylestradiol 3.3mg, chlormadinone 15mg), a monthly, an average of 9.04 years (8 to 11 years), followed by reducing compound ethinyl estrone (ethinylestradiol 2mg, chlorine Progesterone 6mg, 18 norgestrel 6mg), an average of 1.04 years 1 to 1.5 years). The average sister chromatid exchange frequency of the three groups were 5.45 ± 1.10 SD, 7.15 ± 1.22 SD and 5.98 ± 1.13 SD, respectively. The results showed that there was no significant difference in the sister chromatid exchange frequency between the medication group and the normal women group , While the pregnancy group than the medication group and normal women group sister chromatid exchange frequency. This study did not find the proper use of the contraceptive tablets to increase sister chromatid exchange frequency.