1963年Lednicer等报道合成一系列1,2—二苯基3,4—二氢萘系衍生物;经Duncan等动物实验证明,具有良好的避孕效果,其中尤以U—11100A的作用最强。参考国外专利报道,由苯乙酮出发合成2—苯基—6—甲氧—3,4—二萘酮(2)(Ⅰ)。由苯酚出发合成β—四氢吡咯乙基—对溴苯基醚(Ⅱ)。在合成(Ⅱ)时并研究了可代替原料四氢吡咯的二条新路线。由化合物(Ⅰ)和(Ⅱ)经格氏反应得化合物 1963 Lednicer reported a series of synthesis of 1,2-diphenyl 3,4-dihydronaphthalene derivatives; Duncan and other animal experiments proved to have good contraceptive effects, especially U-11100A strongest. Reference to foreign patent reports starting from acetophenone synthesis of 2-phenyl-6-methoxy-3,4-naphthalenone (2) (Ⅰ). Synthesis of β-tetrahydropyrrolylethyl-p-bromophenyl ether from phenol (Ⅱ). In the synthesis of (Ⅱ) and studied two alternative routes to pyrrolidine two new routes. Compounds are Grignard-reacted from compounds (I) and (II)