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目的了解江阴市健康人群百日咳、白喉和破伤风的免疫状况,评价吸附百白破三联试剂(DPT)的效果。方法用百日咳微量凝集方法、白喉间接血凝方法和破伤风间接血凝方法,随机抽取0岁、1～岁、3～岁、5～岁、7～岁、15～岁、≥20岁组健康人群进行百日咳、白喉和破伤风的抗体水平监测。结果百日咳抗体几何平均滴度1∶9.62,抗体阳性率32.26%;白喉抗体几何平均滴度1∶44.45,抗体阳性率89.37%;破伤风抗毒素抗体几何平均滴度1∶118.67,抗体阳性率95.11%。结论江阴市健康人群对白喉、破伤风已形成较好的免疫屏障,人群对百日咳的免疫力还有待提高,必要时可开展重点人群的强化免疫。
Objective To understand the immune status of pertussis, diphtheria and tetanus among healthy population in Jiangyin and evaluate the effect of DPT. Methods The patients were randomly selected from 0 to 1 year old, 3 to 5 years old, 5 to 7 years old, 15 to 20 years old, ≥20 years old group with pertussis microcoagulation method, diphtheria indirect hemagglutination method and tetanic indirect hemagglutination method. The population was monitored for pertussis, diphtheria and tetanus antibody levels. Results The geometric mean titer of pertussis antibody was 1:9.62 and the positive rate of antibody was 32.26%. The geometric mean titer of diphtheria antibody was 1:44.45 and the positive rate of antibody was 89.37%. The geometric mean titer of tetanus antitoxin antibody was 1:118.67 and the positive rate of antibody was 95.11% . Conclusion The healthy population in Jiangyin has a good immune barrier to diphtheria and tetanus. The immunity of the crowd to whooping cough needs to be improved, and the key population can be boosted if necessary.