将雄性SD大鼠置常压缺氧高二氧化碳舱内饲养,通过放射配体结合试验观察肺组织β受体的变化。对照组肺β受体最大结合容量(Bmax)为330±45fmol/mg蛋白,缺氧高二氧化碳4、8周后分别降至260±38和263±30fmol/mg蛋白(P均<0.05),缺氧高二氧化碳前后肺β受体解离常数(kd)无明显变化(P均>0.05)。缺氧高二氧化碳时肺β受体数目的减少能促进肺血管的收缩,故这一变化在缺氧高二氧化碳导致肺动脉高压中可能起一定作用。 Male SD rats were housed under normobaric hypoxia and high carbon dioxide, and the changes of β receptor in lung tissue were observed by radioligand binding assay. In the control group, the maximal lung β receptor binding capacity (Bmax) was 330 ± 45 fmol / mg protein, and hypoxic hypercapnic carbon dioxide decreased to 260 ± 38 and 263 ± 30 fmol / mg protein (P <0.05) Before and after hypercapnia carbon β receptor dissociation constant (kd) no significant change (P all> 0.05). Hypoxia High carbon dioxide decreased the number of lung β receptors can promote pulmonary vascular contraction, so this change in hypoxia and high carbon dioxide may cause pulmonary hypertension may play a role.