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过渡金属配合物催化的潜手性酮不对称加氢反应是制备手性仲醇的一个有效方法,在医药、精细化工及先进材料等领域具有非常重要的应用。采用离子液体-有机溶剂双液相体系,以手性二胺及非手性单膦配体修饰的Ru配合物为催化剂,催化潜手性酮的不对称加氢反应。考察了反应温度、氢气压力、溶剂和离子液体用量等因素对反应结果的影响,同时也考察了催化剂在反应体系中的流失情况。结果表明离子液体可以有效地负载手性催化剂,催化剂在反应过程中的流失量很低,可以实现简单的萃取分离。
Asymmetric hydrogenation catalyzed by transition metal complexes is an effective method for the preparation of chiral secondary alcohols. It has very important applications in the fields of medicine, fine chemicals and advanced materials. The asymmetric hydrogenation of underlying ketones was catalyzed by the ionic liquid-organic solvent two-liquid system and the Ru complexes modified by chiral diamines and achiral monophosphine ligands as catalysts. The effects of reaction temperature, pressure of hydrogen, amount of solvent and ionic liquid on the reaction results were investigated. Meanwhile, the loss of catalyst in the reaction system was also investigated. The results show that the ionic liquid can effectively support the chiral catalyst, and the loss of the catalyst during the reaction is very low, and the simple extraction and separation can be realized.