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为了明确胶原蛋白Ⅳ（ColⅣ）和层粘蛋白（LN）在膀胱癌基底膜中的表达与含量，采用免疫组织化学方法（SABC法）测定35例膀胱移行细胞癌组织基底膜结构糖蛋白──ColⅣ、LN含量和分布。结果浅表性膀胱移行细胞癌基底膜ColⅣ和LN含量高，且呈连续分布；浸润性膀胱移行细胞癌基底膜ColⅣ和LN含量低，呈不连续分布；病理级别低、分化程度高的膀胱癌基底膜ColⅣ和LN与病理级别高、分化程度低的膀胱癌比较，前者的含量高、分布连续。提示结构糖蛋白──ColⅣ和LN在浸润性膀胱移行细胞癌基底膜中缺失，而在浅表性膀胱移行细胞癌基底膜中含量多，分布连续；基底膜ColⅣ和LN的含量随着分化程度的下降、病理级别的上升而减少。
In order to clarify the expression and content of col Ⅳ and laminin in bladder cancer, the immunohistochemistry (SABC method) was used to detect the expression of glycoprotein in 35 cases of bladder transitional cell carcinoma Col Ⅳ, LN content and distribution. Results The expression of Col Ⅳ and LN in superficial bladder transitional cell carcinoma was high and continuously distributed. The content of Col Ⅳ and LN in invasive bladder transitional cell carcinoma was low and presented discontinuously; the pathological grade was low and the differentiation was high Basement membrane col Ⅳ and LN with high pathological grade, low degree of differentiation of bladder cancer compared to the former content is high, continuous distribution. Tip structure glycoprotein ─ ─ Col Ⅳ and LN in invasive bladder transitional cell carcinoma of the basement membrane missing, and in superficial bladder transitional cell carcinoma of the basement membrane content and distribution of continuous; basement membrane Col Ⅳ and LN content with the degree of differentiation Decline, the pathological level rise and reduce.