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目的观察三维适形放疗同步单药化疗治疗老年局部晚期非小细胞肺癌(NSCLC)的临床疗效和毒副反应。方法放疗选用三维适形放疗(3D-CRT),化疗选用长春瑞滨(盖诺)单药,25mg/m2,静脉推注,d1,8,3周重复。于放疗第1天开始化疗,放疗期间共行2个周期化疗,放疗结束后再化疗2个周期。结果完全缓解(CR)21.2%,部分缓解(PR)54.5%,总有效率(RR)75.8%。Ⅲ～Ⅳ度不良反应发生率比较低。结论 3D-CRT同步单药化疗治疗老年局部晚期NSCLC疗效较好,毒副反应能耐受,安全可行。
Objective To observe the clinical efficacy and side effects of three-dimensional conformal radiotherapy combined with single-agent chemotherapy in the treatment of elderly locally advanced non-small cell lung cancer (NSCLC). Methods Three-dimensional conformal radiotherapy (3D-CRT) was used in the radiotherapy. Vincristine (25 mg / m2) alone was used for chemotherapy. Intravenous bolus injection was repeated at d1, 8, and 3 weeks. In the first day of radiotherapy chemotherapy, radiotherapy during the two cycles of chemotherapy, radiotherapy after the end of 2 cycles of chemotherapy. Results Complete response (CR) 21.2%, partial response (PR) 54.5%, total effective rate (RR) 75.8%. Ⅲ ~ Ⅳ adverse reaction rate is relatively low. Conclusions 3D-CRT simultaneous single-agent chemotherapy is superior in the treatment of advanced local advanced NSCLC in elderly patients. The toxicity of side effects can be tolerated safely and practically.