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A 33-year -old woman with T 4c N 3 breast cancer with metastases in the skeleton(M1)received five cycles of 5-fluorouracil,epirubicin,and cyclophosphamide(FEC reg-imen)before conception and during the fir st trimester.Salvage radiotherapy(28Gy )was delivered during the 17th week.Tamoxifen and zolendronic acid were also adminis-tered throughout the second and thir d trimesters.Thepatient was not aware of her pregnancy until the 28th week.A female phenotypically normal infa nt was delivered in the35th week of gestation by cesarean se ction.The child is functioning normally 12months afte r delivery.The litera-ture of anthracycline treatment dur ing conception and the first trimester is reviewed.The effects of tamoxifen and biphosphonate therapy on the fetus d uring pregnancy are also discussed.
A 33-year -old woman with T 4c N 3 breast cancer with metastases in the skeleton (M1) received five cycles of 5-fluorouracil, epirubicin, and cyclophosphamide (FEC reg-imen) before conception and during the fir st trimester. radiotherapy (28Gy) was delivered during the 17th week. Tamoxifen and zolendronic acid were also adminis-tered throughout the second and thir d trimesters. Thepatient was not aware of her pregnancy until the 28th week. A female phenotypically normal infa nt was delivered in the 35th week of gestation by cesarean se ction. The child is functioning normally 12 monthsth afte r delivery.The litera-ture of anthracycline treatment dur ing conception and the first trimester is reviewed. the effects of tamoxifen and biphosphonate therapy on the fetus d uring pregnancy are also discussed.