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目的:观察妊娠高血压综合征(妊高征)的高危孕妇补钙预防妊高征发生的效果及妊高征和其高危孕妇血清钙磷代谢的变化。方法:采用前瞻性、双盲随机方法自孕28周起给妊高征高危孕妇连续服钙1.5g/d直至分娩。结果:服钙组和安慰剂组妊高征的发生率差异显著;妊高征、高危孕妇与正常孕妇的血清钙、磷水平无显著性差异。服钙组、安慰剂组在常孕妇对照组孕期、产时的血清钙、磷水平亦均无显著性差异;各组脐血比母血清钙、磷水平均明显升高,且均具有显著性差异。结论:孕妇要合理摄取营养(富含钙质的饮食),及药补所需钙量,从而保证胎儿健康发育及预防妊高征的发生。
AIM: To observe the effect of calcium supplementation in preventing pregnancy-induced hypertension (PIH) in pregnancy-induced hypertension syndrome (PIH) and the changes of serum calcium and phosphorus metabolism in pregnancy-induced hypertension and its high-risk pregnant women. Methods: A prospective, double-blind, randomized, double-blind, randomized trial of calcium supplementation of 1.5 g / d for pregnant women at high risk of pregnancy-induced hypertension until 28 weeks after delivery. Results: There were significant differences in the incidence of PIH between the calcium group and the placebo group. There was no significant difference in the serum calcium and phosphorus levels between the PIH and the high-risk pregnant women and the normal pregnant women. Calcium group and placebo group in pregnant women control group during pregnancy, during delivery of serum calcium and phosphorus levels were also no significant difference; cord blood than the mother’s serum calcium and phosphorus levels were significantly increased, and both were significant difference. Conclusion: Pregnant women should take reasonable nutrition (calcium-rich diet), and the amount of calcium required for the drug to ensure the healthy fetal development and prevention of pregnancy-induced hypertension.