Ｆｏｏｔｅ与Ｏｌｓｓｏｎ等于 1980年发现Ｅ .ｃｏｌｉ 6 氧 甲基嘌呤 ＤＮＡ甲基转移酶 (ＭＧＭＴ或ＡＧＴ ,ＥＣ2 .1.1.6 3)与Ｏ6 甲基鸟嘌呤 (Ｏ6ｍＧ)的修复有关。Ｋａｕｔｉａｎｉｎｅｎ等又于 1986年发现肿瘤转化株细胞内的ＭＧＭＴ活力成倍增高。随后 ,人们发现2 0 % Foote and Olsson et al. Found in 1980 that E.coli 6-oxomethine DNA methyltransferase (MGMT or AGT, EC2.1.1.63) was involved in the repair of O6-methylguanine (O6mG). In 1986, Kautianinen et al. Found that MGMT activity in tumor-transformed cells multiplied exponentially. Subsequently, it was found 20%